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How does cellular respiration release the energy stored in glucose as ATP?

Use models to describe how cellular respiration converts the chemical energy in glucose into ATP, comparing aerobic and anaerobic respiration (North Carolina Standard Course of Study, Biology, LS.Bio.3).

A standard-level answer on cellular respiration for the North Carolina Biology EOC: the equation, the role of the mitochondrion, the difference between aerobic and anaerobic respiration, and fermentation.

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  1. What this topic is asking
  2. The equation and the mitochondrion
  3. Aerobic versus anaerobic respiration
  4. Try this

What this topic is asking

North Carolina LS.Bio.3 asks you to model how cellular respiration converts the energy in glucose into ATP. For the Biology EOC you need the equation, the role of the mitochondrion, and the difference between aerobic respiration (with oxygen, lots of ATP) and anaerobic respiration or fermentation (without oxygen, little ATP). Items often ask you to compare the two or to spot the products.

The equation and the mitochondrion

The balanced equation is the reverse of photosynthesis:

C6H12O6+6O26CO2+6H2O+energy (ATP)C_6H_{12}O_6 + 6O_2 \rightarrow 6CO_2 + 6H_2O + \text{energy (ATP)}

In words: glucose plus oxygen produces carbon dioxide plus water plus energy (ATP). The reactants are glucose and oxygen; the products are carbon dioxide, water, and ATP. A small amount of ATP is made in the cytoplasm (in glycolysis), but most of it is made inside the mitochondrion. The mitochondrion's inner membrane is folded into cristae, increasing the surface area for the reactions, which is why cells that need a lot of energy have many mitochondria.

Respiration happens in all living cells, all the time, including plant cells. Plants photosynthesise in the light and respire constantly, so do not assume only animals respire.

Aerobic versus anaerobic respiration

Anaerobic respiration takes two common forms:

  • In animal cells (lactic acid fermentation). During hard exercise, muscle cells run low on oxygen and produce lactic acid, which builds up and contributes to muscle fatigue and soreness. When oxygen returns, the lactic acid is broken down.
  • In yeast and some microbes (alcoholic fermentation). Yeast produces ethanol and carbon dioxide. This is the basis of bread rising (carbon dioxide) and brewing (ethanol).

Both forms release far less ATP than aerobic respiration, which is why anaerobic respiration is a short-term backup rather than a long-term solution.

Feature Aerobic respiration Anaerobic respiration
Oxygen Required Not required
ATP yield High (many ATP) Low (few ATP)
Main site Mitochondrion Cytoplasm
Products Carbon dioxide and water Lactic acid (animals); ethanol and carbon dioxide (yeast)

Try this

Q1. Write the word equation for aerobic cellular respiration. [2]

  • Cue. Glucose plus oxygen produces carbon dioxide plus water plus energy (ATP).

Q2. State two differences between aerobic and anaerobic respiration. [2]

  • Cue. Aerobic uses oxygen and yields a lot of ATP; anaerobic uses no oxygen and yields little ATP (and produces lactic acid, or ethanol and carbon dioxide).

Exam-style practice questions

Practice questions written in the style of NCDPI exam questions on this dot point, with worked answer explainers. The year tag is the paper they imitate, not the source.

NC Biology EOC (style)1 marksWhich are the products of aerobic cellular respiration? (A) Glucose and oxygen. (B) Carbon dioxide, water, and ATP. (C) Light and oxygen. (D) Only glucose.
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A 1-point item on the respiration equation.

The correct answer is B. Aerobic respiration breaks down glucose using oxygen to release energy (ATP), producing carbon dioxide and water. A lists the reactants, C is photosynthesis-related, and D is incomplete.

Reactants in: glucose and oxygen; products out: carbon dioxide, water, and energy (ATP).

NC Biology EOC (style)2 marksA runner sprints hard and their muscles run low on oxygen. (a) Name the type of respiration the muscle cells switch to. (b) State the product that builds up and causes muscle fatigue.
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A 2-point item on anaerobic respiration.

(a) 1 point: anaerobic respiration (lactic acid fermentation).
(b) 1 point: lactic acid (lactate) builds up in the muscles, contributing to fatigue and soreness.

Markers reward naming anaerobic respiration and identifying lactic acid as the product.

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