How does cellular respiration release the energy stored in glucose, and how does it connect to photosynthesis?
Use a model to explain how cellular respiration releases energy from glucose as ATP, and how it relates to photosynthesis in cycling matter and energy (Tennessee Academic Standards for Science, Biology I, BIO1.LS1).
A standard-level answer on cellular respiration for the Tennessee Biology I EOC: the overall equation, aerobic respiration in the mitochondria, ATP as the energy currency, anaerobic respiration (fermentation), and how respiration is the reverse of photosynthesis.
Reviewed by: AI editorial process; not yet individually human-reviewed
Have a quick question? Jump to the Q&A page
Jump to a section
What this topic is asking
The Tennessee LS1 standards ask you to model how cellular respiration releases the energy stored in glucose so the cell can use it, and how respiration relates to photosynthesis. For the Biology I EOC that means knowing the overall equation, that aerobic respiration happens in the mitochondria and produces ATP, what happens without oxygen (fermentation), and the cause-and-effect relationship between respiration and photosynthesis in cycling matter and energy. The respiration equation and the "reverse of photosynthesis" idea are high-frequency items.
The overall reaction
Notice that this is the photosynthesis equation written backward. Anchoring that comparison is one of the best ways to remember both: photosynthesis stores energy by building glucose; respiration releases that energy by breaking glucose down.
ATP: the energy currency
The energy released from glucose is not used directly; it is transferred to molecules of ATP (adenosine triphosphate), the cell's usable energy currency. When a cell needs energy, it breaks a bond in ATP to release it. So the point of respiration is to convert the chemical energy in glucose into the form (ATP) the cell can actually spend on movement, active transport, building molecules, and other work. Energy is transformed, not created: chemical energy in glucose becomes chemical energy in ATP, with some lost as heat.
Where it happens: the mitochondrion
Most aerobic respiration occurs in the mitochondrion. Its folded inner membrane gives a large surface area for the reactions, and cells with high energy demands (muscle, nerve) contain many mitochondria. This is the link back to the organelles standard: a high mitochondrion count signals a high energy demand. A small first step of respiration (glycolysis) happens in the cytoplasm, but the bulk of the ATP comes from the mitochondrion when oxygen is present.
Without oxygen: fermentation
The EOC may contrast the two: with oxygen, a cell uses aerobic respiration and gets a lot of ATP; without oxygen, it falls back on fermentation, which is quick but yields little ATP. This is why muscles can work briefly without enough oxygen but tire and ache as lactic acid accumulates.
The link to photosynthesis
Because respiration and photosynthesis are near-reverses, their inputs and outputs interlock. Respiration's products (carbon dioxide and water) are photosynthesis's reactants; photosynthesis's products (glucose and oxygen) are respiration's reactants. Together they cycle carbon and oxygen between organisms and the atmosphere and pass the Sun's energy through living things. Plants do both: they photosynthesize in the light and respire all the time.
Try this
Q1. Write the overall equation for aerobic respiration in words, naming the reactants and products. [2]
- Cue. Glucose plus oxygen produce carbon dioxide plus water, releasing energy (ATP).
Q2. Explain why a cell that does a lot of active transport tends to contain many mitochondria. [2]
- Cue. Active transport requires energy (ATP); mitochondria are the site of aerobic respiration that produces ATP, so a cell needing a lot of energy has many mitochondria to supply it.
Exam-style practice questions
Practice questions written in the style of TDOE exam questions on this dot point, with worked answer explainers. The year tag is the paper they imitate, not the source.
TN Biology I EOC (2023 released style)1 marksIn which organelle does most cellular respiration occur in a eukaryotic cell? (A) Chloroplast. (B) Nucleus. (C) Mitochondrion. (D) Ribosome.Show worked answer →
A 1-point multiple-choice item on the site of respiration.
The correct answer is C. Aerobic cellular respiration takes place mainly in the mitochondrion, which is why cells with high energy demands have many mitochondria. The chloroplast (A) is the site of photosynthesis, the nucleus (B) stores DNA, and the ribosome (D) builds proteins.
TN Biology I EOC (2024 released style)2 marksCellular respiration and photosynthesis are often described as opposite processes. (a) Write what cellular respiration uses and produces. (b) Explain how the two processes together cycle matter.Show worked answer →
A 2-point item on the respiration-photosynthesis relationship.
(a) 1 point: cellular respiration uses glucose and oxygen and produces carbon dioxide and water (plus energy as ATP): .
(b) 1 point: the carbon dioxide and water released by respiration are the reactants of photosynthesis, and the glucose and oxygen made by photosynthesis are the reactants of respiration, so carbon and oxygen cycle between organisms and the air.
Markers reward the correct reactants and products and the idea that the outputs of one process are the inputs of the other.
Related dot points
- Use a model to explain how photosynthesis transforms light energy into the chemical energy of sugars, using carbon dioxide and water (Tennessee Academic Standards for Science, Biology I, BIO1.LS1).
A standard-level answer on photosynthesis for the Tennessee Biology I EOC: the overall equation, the reactants and products, the role of chloroplasts and chlorophyll, where the energy goes, and how photosynthesis connects to cellular respiration in the cycling of matter and energy.
- Construct an explanation that the essential functions of life are carried out by the four macromolecules (carbohydrates, lipids, proteins, and nucleic acids) built from monomers (Tennessee Academic Standards for Science, Biology I, BIO1.LS1).
A standard-level answer on biological macromolecules for the Tennessee Biology I EOC: carbohydrates, lipids, proteins, and nucleic acids, their monomers, their functions, and why protein shape determines what a protein can do.
- Develop and use models to relate the structure of cell organelles to their function in plant and animal cells (Tennessee Academic Standards for Science, Biology I, BIO1.LS1).
A standard-level answer on organelles for the Tennessee Biology I EOC: the nucleus, ribosomes, endoplasmic reticulum, Golgi apparatus, mitochondria, chloroplasts, lysosomes, the cell membrane, and the plant-only cell wall and vacuole, each as a structure-and-function pair.
- Construct an explanation for how matter cycles through ecosystems, including the carbon, nitrogen, and water cycles, and the role of photosynthesis, respiration, and decomposers (Tennessee Academic Standards for Science, Biology I, BIO1.LS2).
A standard-level answer on biogeochemical cycles for the Tennessee Biology I EOC: how the carbon, nitrogen, and water cycles move matter through ecosystems, the role of photosynthesis and respiration in the carbon cycle, and the role of decomposers and bacteria.
- Use a model to illustrate how energy flows through an ecosystem from producers to consumers and decomposers, and why it decreases at each trophic level (Tennessee Academic Standards for Science, Biology I, BIO1.LS2).
A standard-level answer on energy flow for the Tennessee Biology I EOC: producers, consumers, and decomposers, food chains and food webs, trophic levels, energy pyramids, and the 10 percent rule for energy transfer.
Sources & how we know this
- Tennessee Academic Standards for Science — Tennessee Department of Education (2022)
- TNReady EOC Science Item Release (Biology and Chemistry) — Tennessee Department of Education (2018)